DoseSafe Calculator

Safety database

Regulatory status, safety summaries, calculation policy, and source summaries for the medications known to this app. Records are reference-only and must be verified against current official sources.

Retatrutide
Investigational / not FDA-approved

Also known as: LY3437943

Class
Investigational incretin receptor agonist
Mechanism
Investigational GIP, GLP-1, and glucagon receptor agonist
Regulatory status
Investigational / not FDA-approved
Dose presets allowed in this app
No — calculation only

Safety summary

Retatrutide is investigational and not FDA-approved. This app does not recommend retatrutide dosing. Calculations are allowed only from user-entered, clinician-provided values.

Calculation policy

  • No dose recommendations available in this app.
  • Only calculation from user-entered, clinician-provided values is allowed.
  • Vial-strength options are "amount of powder in the vial" values, never dosing advice.
Source summaries
FDA — Risks of compounded GLP-1 type drugs and dosing errors
regulatory

FDA has warned about dosing errors with compounded injectable GLP-1-type products, often due to confusion between mg, mL, and syringe units. Compounded drugs are not FDA-approved; FDA does not verify their safety, effectiveness, or quality before marketing.

U.S. Food & Drug AdministrationRetrieved 2026-05-28Reliability 5/5
FDA — Retatrutide cannot be used in compounding
regulatory

FDA states that retatrutide cannot be used in compounding under federal law. Retatrutide is investigational and is legally available only through Eli Lilly clinical trials.

U.S. Food & Drug AdministrationRetrieved 2026-05-28Reliability 5/5
Eli Lilly — Retatrutide (LY3437943) investigational status
manufacturer

Retatrutide is an investigational GIP, GLP-1, and glucagon receptor agonist under clinical development. It is not approved by any regulatory agency.

Eli Lilly and CompanyRetrieved 2026-05-28Reliability 4/5

Source summaries are provided for transparency only and may be out of date. Verify against current official sources before relying on them.